Human S100 Calcium Binding Protein A12,S100A12 ELISA KIT

SKU: E6110Hu

Size:96 Tests-1 Kit

Background:S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. {ECO:0000269|PubMed:11522286, ECO:0000269|PubMed:17208591, ECO:0000269|PubMed:18292089, ECO:0000269|PubMed:19386136}.

Research_area:

Applications:ELISA

Target_protein:S100A12

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.45ng/ml

Detection range:7-1500ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:S100 calcium binding protein A12;Calgranulin-C

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P80511

MASS(Da):10575

GeneID:6283

Synonyms:S100A12

Gene names:S100A12

Standard solution:1600ng/ml