Human Proprotein convertase subtilisin;kexin type 9,PCSK9 ELISA KIT

SKU: E7474Hu

Size:96 Tests-1 Kit

Background:Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}.

Research_area:

Applications:ELISA

Target_protein:PCSK9

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.61ng/ml

Detection range:1-380ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Proprotein convertase subtilisin;kexin type 9

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8NBP7

MASS(Da):74286

GeneID:255738

Synonyms:PCSK9 NARC1 PSEC0052

Gene names:PCSK9

Standard solution:400ng/ml