Human Probable G-protein coupled receptor 52,GPR52 ELISA KIT

SKU: E6450Hu

Size:96 Tests-1 Kit

Background:Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000269|PubMed:24587241, ECO:0000269|PubMed:25738228}.

Research_area:

Applications:ELISA

Target_protein:GPR52

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.39ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Probable G-protein coupled receptor 52

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y2T5

MASS(Da):41354

GeneID:9293

Synonyms:GPR52

Gene names:GPR52

Standard solution:4000ng/L