Human Potassium Channel Subfamily K Member 9, KCNK9 ELISA Kit

SKU: E1765Hu

Size:96 Tests-1 Kit

Background:Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene. This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate. Phorbol 12-myristate 13-acetate is also known as 12-O-tetradecanoylphorbol-13-acetate (TPA). TASK channels are additionally inhibited by hormones and transmitters that signal through GqPCRs. The resulting cellular depolarization is thought to regulate processes such as motor control and aldosterone secretion. Despite early controversy about the exact mechanism underlying this inhibition, the current view is that Diacyl-glycerol, produced by the breakdown of Phosphatidylinositol-4,5-bis-phosphate by Phospholipase Cβ causes channel closure.

Research_area:Neuroscience

Applications:ELISA

Target_protein:KCNK9

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.92ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Potassium Channel subfamily K member 9

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NPC2

MASS(Da):42,264

GeneID:51305

Synonyms:Acid-sensitive potassium Channel protein TASK-3;BIBARS;K2p9.1;KCNK9;KT3.2;Potassium Channel subfamily K member 9;TASK3;TASK-3;TASK32;TWIK-related acid-sensitive K(+ Channel 3;Two pore K(+ Channel KT3.2;Two pore potassium Channel KT3.2

Gene names:KCNK9

Standard solution:8000ng/L