Human Poliovirus Receptor, PVR ELISA Kit

SKU: E5895Hu

Size:96 Tests-1 Kit

Background:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.

Research_area:Microbiology

Applications:ELISA

Target_protein:PVR

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.58ng/mL

Detection range:3-900ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Poliovirus receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15151

MASS(Da):45,303

GeneID:5817

Synonyms:CD antigen CD155;CD155;HVED;NECL5;Necl-5;Nectin-like protein 5;Poliovirus receptor;PVR;PVS;TAGE4

Gene names:PVR

Standard solution:960ng/mL