Human PILRA ELISA Kit PicoKine®

SKU: EK2255

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: PILRA

Specificity: Natural and recombinant human PILRA

Background: Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene. Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q20-T196

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Reference:

Uniprot ID: Q9UKJ1

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 29992

Protein Name: Paired immunoglobulin-like type 2 receptor alpha

Gene Full Name: paired immunoglobin like type 2 receptor alpha

Synonyms: Cell surface receptor FDF03; FDF03; Inhibitory receptor PILR alpha; PILRA; PILRα