Human Oxidized Low-density Lipoprotein Receptor 1, OLR1 ELISA Kit

SKU: E3225Hu

Size:96 Tests-1 Kit

Background:Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:OLR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.022ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Oxidized Low-Density Lipoprotein Receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78380

MASS(Da):30,959

GeneID:4973

Synonyms:C-type lectin domain family 8 member A;hLOX-1;Lectin-like oxidized LDL receptor 1;Lectin-like oxLDL receptor 1;Lectin-type oxidized LDL receptor 1;LOX-1;OLR 1;OLR1;Oxidized low-density lipoprotein receptor 1;Oxidized low-density lipoprotein receptor 1, soluble form;Ox-LDL receptor 1

Gene names:OLR1

Standard solution:32ng/ml