Human Nucleoside Diphosphate Kinase A, NME1 ELISA Kit

SKU: E5803Hu

Size:96 Tests-1 Kit

Background:Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:NME1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.28ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nucleoside Diphosphate Kinase A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15531

MASS(Da):17,149

GeneID:4830

Synonyms:GAAD;Granzyme A-activated DNase;Metastasis inhibition factor nm23;NDK A;NDP kinase A;NM23-H1;NME 1;NME1;Nucleoside diphosphate kinase A;Tumor metastatic process-associated protein

Gene names:NME1

Standard solution:2400ng/L