Human N-lysine Methyltransferase Smyd2, SMYD2 ELISA Kit

SKU: E5782Hu

Size:96 Tests-1 Kit

Background:Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:SMYD2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.18ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:N-lysine methyltransferase SMYD2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NRG4

MASS(Da):49,688

GeneID:56950

Synonyms:Histone methyltransferase SMYD2;HSKM-B;KMT3C;Lysine N-methyltransferase 3C;N-lysine methyltransferase SMYD2;SET and MYND domain-containing protein 2;SMYD2;ZMYND14

Gene names:SMYD2

Standard solution:3200ng/L