Human Myomegalin, PDE4DIP ELISA Kit

SKU: E5716Hu

Size:96 Tests-1 Kit

Background:Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PDE4DIP

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.45ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myomegalin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5VU43

MASS(Da):265,103

GeneID:9659

Synonyms:Cardiomyopathy-associated protein 2;CMYA2;MMGL;Myomegalin;PDE4DIP;Phosphodiesterase 4D-interacting protein

Gene names:PDE4DIP

Standard solution:6400ng/L