Human Myc Box-dependent-interacting Protein 1, BIN1 ELISA Kit

SKU: E2847Hu

Size:96 Tests-1 Kit

Background:Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed: 2$475.00|$350.005653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed: 27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed: 8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed: 28893863).

Research_area:Others

Applications:ELISA

Target_protein:BIN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.97ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myc Box-Dependent-Interacting Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00499

MASS(Da):64,699

GeneID:274

Synonyms:Amphiphysin II;Amphiphysin-like protein;BIN 1;BIN1;Box-dependent myc-interacting protein 1;Bridging integrator 1;Myc box-dependent-interacting protein 1

Gene names:BIN1

Standard solution:4000ng/L