Human Mucin-4, MUC4 ELISA Kit

SKU: E1940Hu

Size:96 Tests-1 Kit

Background:May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:MUC4

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.48pg/ml

Detection range:10-3000pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Mucin-4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99102

MASS(Da):231,518

GeneID:4585

Synonyms:Ascites sialoglycoprotein;Ascites sialoglycoprotein 1;Ascites sialoglycoprotein 2;ASGP;ASGP-1;ASGP-2;MUC 4;MUC4;MUC-4;Mucin-4;Mucin-4 alpha chain;Mucin-4 beta chain;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin

Gene names:MUC4

Standard solution:3200pg/ml