Human Membrane Co Factor Protein, MCP ELISA Kit

SKU: E0275Hu

Size:96 Tests-1 Kit

Background:Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed: 7708671, PubMed: 9379894, PubMed: 11260136, PubMed: 11971006).

Research_area:Immunology

Applications:ELISA

Target_protein:CD46

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.51ng/ml

Detection range:1-400ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Membrane Cofactor Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15529

MASS(Da):43,747

GeneID:4179

Synonyms:CD 46;CD antigen CD46;CD46;Membrane cofactor protein;TLX;Trophoblast leukocyte common antigen

Gene names:CD46

Standard solution:480ng/ml