Human Matrix metalloproteinase 2;Gelatinase A,MMP2 ELISA KIT

SKU: E0904Hu

Size:96 Tests-1 Kit

Background:Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Research_area:

Applications:ELISA

Target_protein:MMP2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.08ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Matrix metalloproteinase 2;Gelatinase A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08253

MASS(Da):73882

GeneID:4313

Synonyms:MMP2 CLG4A

Gene names:MMP2

Standard solution:24ng/ml