Human Malate Dehydrogenase, MDH2 ELISA Kit

SKU: E5627Hu

Size:96 Tests-1 Kit

Background:Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Because malate dehydrogenase is closely tied to the citric acid cycle, regulation is highly dependent on TCA products.[8] Citrate also affects MDH activity by very complex manner. It inhibits the reduction of oxaloacetate under all conditions. Citrate also inhibits malate oxidation, but only at low malate or NAD concentrations.

Research_area:Others

Applications:ELISA

Target_protein:MDH2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.59ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Malate dehydrogenase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P40926

MASS(Da):35,503

GeneID:4191

Synonyms:DEE51;EIEE51;Malate dehydrogenase, mitochondrial;MDH;MDH2;MGC:3559;M-MDH;MOR1

Gene names:MDH2

Standard solution:3200ng/L