Human Lysyloxidase Homolog 3, LOXL3 ELISA Kit

SKU: E5620Hu

Size:96 Tests-1 Kit

Background:Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed: 17018530, PubMed: 28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed: 17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed: 28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed: 28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed: 28065600). [Isoform 1]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed: 17018530). [Isoform 2]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed: 17018530).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:LOXL3

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.03ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Lysyl Oxidase Homolog 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P58215

MASS(Da):83,166

GeneID:84695

Synonyms:LOXL 3;LOXL3;Lysyl oxidase homolog 3;Lysyl oxidase-like protein 3

Gene names:LOXL3

Standard solution:4800ng/L