Human Liver Carboxylesterase 1, CES1 ELISA Kit

SKU: E2395Hu

Size:96 Tests-1 Kit

Background:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed: 7980644, PubMed: 9169443, PubMed: 9490062, PubMed: 18762277). Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed: 7980644, PubMed: 9169443, PubMed: 9490062, PubMed: 18762277). Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed: 7980644). Catalyzes the transesterification of cocaine to form cocaethylene (PubMed: 7980644). Displays fatty acid ethyl ester Synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed: 7980644). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed: 21049984). Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed: 18762277, PubMed: 16024911, PubMed: 11015575, PubMed: 16971496). First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed: 18762277, PubMed: 18599737, PubMed: 16971496).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:CES1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.46ng/ml

Detection range:1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Liver Carboxylesterase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23141

MASS(Da):62,521

GeneID:1066

Synonyms:ACAT;Acyl-coenzyme A:cholesterol acyltransferase;Brain carboxylesterase hBr1;Carboxylesterase 1;CE-1;CEH;CES 1;CES1;Cholesteryl ester hydrolase;Cocaine carboxylesterase;Egasyn;hCE-1;HMSE;Liver carboxylesterase 1;Methylumbelliferyl-acetate deacetylase 1;Monocyte/macrophage serine esterase;REH;Retinyl ester hydrolase;Serine esterase 1;TGH;Triacylglycerol hydrolase

Gene names:CES1

Standard solution:48ng/ml