Human Kappa-type Opioid Receptor, OPRK1 ELISA Kit

SKU: E4216hu

Size:96 Tests-1 Kit

Background:G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Research_area:Others

Applications:ELISA

Target_protein:OPRK1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Kappa-Type Opioid Receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P41145

MASS(Da):42,645

GeneID:4986

Synonyms:Kappa-type opioid receptor;KOR-1;K-OR-1;OPRK 1;OPRK1

Gene names:OPRK1

Standard solution:16ng/ml