Human Integrin Beta-7, ITGB7 ELISA Kit

SKU: E5486Hu

Size:96 Tests-1 Kit

Background:Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:ITGB7

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.051ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Integrin Beta-7

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P26010

MASS(Da):86,903

GeneID:3695

Synonyms:Gut homing receptor beta subunit;Integrin beta-7;ITGB 7;ITGB7

Gene names:ITGB7

Standard solution:48ng/ml