Human Indoleamine 2, 3-dioxygenase, IDO ELISA Kit

SKU: E0796Hu

Size:96 Tests-1 Kit

Background:Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed: 17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed: 25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed: 25691885). Acts as a suppressor of anti-tumor immunity (PubMed: 23103127, PubMed: 25157255, PubMed: 14502282, PubMed: 25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed: 25691885). Protects the fetus from maternal immune rejection (PubMed: 25691885).

Research_area:Metabolism

Applications:ELISA

Target_protein:IDO1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.16ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Indoleamine 2,3-Dioxygenase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P14902

MASS(Da):45,326

GeneID:3620

Synonyms:IDO 1;IDO1;IDO-1;Indoleamine 2,3-dioxygenase 1;Indoleamine-pyrrole 2,3-dioxygenase

Gene names:IDO1

Standard solution:96ng/ml