Human High mobility group protein B3,HMGB3 ELISA KIT

SKU: E7013Hu

Size:96 Tests-1 Kit

Background:Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:O54879, ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618}.

Research_area:

Applications:ELISA

Target_protein:HMGB3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-6.4ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:High mobility group protein B3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15347

MASS(Da):22980

GeneID:3149

Synonyms:HMGB3 HMG2A HMG4

Gene names:HMGB3

Standard solution:12.8ng/ml