Human HEXA ELISA Kit PicoKine®

SKU: EK2215

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: HEXA

Specificity: Natural and recombinant human HEXA

Background: Hexosaminidase A (alpha polypeptide), also known as HEXA, is an enzyme that in humans is encoded by the HEXA gene, located on the 15th chromosome. This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Immunogen: Expression system for standard: NS0; Immunogen sequence: M1-T529

Clonality:

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Reconstitution:

Reference:

Uniprot ID: P06865

Host:

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Calculated Molecular Weight:

Gene ID: 3073

Protein Name: Beta-hexosaminidase subunit alpha

Gene Full Name: hexosaminidase subunit alpha

Synonyms: HEXA; Hexosaminidase subunit A; TSD