Human GPNMB/Osteoactivin ELISA Kit PicoKine®

SKU: EK1251

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: GPNMB

Specificity: Natural and recombinant human GPNMB

Background: Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. In osteoblast progenitor cells, GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.

Immunogen: Expression system for standard: NS0; Immunogen sequence: K23-P486

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Uniprot ID: Q14956

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 10457

Protein Name: Transmembrane glycoprotein NMB

Gene Full Name: glycoprotein nmb

Synonyms: glycoprotein nmb; HGFIN; NMB; PLCA3; Gpnmb