Human Glutamate[NMDA]receptor subunit epsilon-1,GRIN2A ELISA KIT

SKU: E4452Hu

Size:96 Tests-1 Kit

Background:Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:Q00959, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}.

Research_area:

Applications:ELISA

Target_protein:GRIN2A

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.11ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamate[NMDA]receptor subunit epsilon-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12879

MASS(Da):165283

GeneID:2903

Synonyms:GRIN2A NMDAR2A

Gene names:GRIN2A

Standard solution:9600ng/L