Human Frataxin, Mitochondrial, FXN ELISA Kit

SKU: E5308Hu

Size:96 Tests-1 Kit

Background:Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:FXN

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.81ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Frataxin, Mitochondrial

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q16595

MASS(Da):23,135

GeneID:2395

Synonyms:d-FXN;Frataxin intermediate form;Frataxin mature form;Frataxin(56-210;Frataxin(78-210;Frataxin(81-210;Frataxin, mitochondrial;Friedreich ataxia protein;FXN;i-FXN;m56-FXN;m78-FXN;m81-FXN;

Gene names:FXN

Standard solution:3200ng/L