Human Eyes Absent Homolog 2, EYA2 ELISA Kit

SKU: E5272Hu

Size:96 Tests-1 Kit

Background:Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed: 12500905, PubMed: 23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed: 19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed: 12500905).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:EYA2

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.25ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Eyes Absent Homolog 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00167

MASS(Da):59,232

GeneID:2139

Synonyms:EYA 2;EYA2;Eyes absent homolog 2

Gene names:EYA2

Standard solution:1280ng/L