Human Estrogen Receptor Beta, ER-beta ELISA Kit

SKU: E3287Hu

Size:96 Tests-1 Kit

Background:Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed: 20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Research_area:Others

Applications:ELISA

Target_protein:ESR2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Estrogen Receptor Beta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92731

MASS(Da):59,216

GeneID:2100

Synonyms:ER-beta;ESR 2;ESR2;Estrogen receptor beta;Nuclear receptor subfamily 3 group A member 2

Gene names:ESR2

Standard solution:24ng/ml