Human dolichyl-diphosphooligosaccharide-protein glycosyltransferase,DDOST;OST-48 ELISA KIT

SKU: E5202Hu

Size:96 Tests-1 Kit

Background:Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. {ECO:0000250|UniProtKB:Q05052, ECO:0000269|PubMed:22467853, ECO:0000305}.; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853). {ECO:0000250|UniProtKB:Q05052, ECO:0000269|PubMed:22467853}.

Research_area:

Applications:ELISA

Target_protein:DDOST

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.048ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:dolichyl-diphosphooligosaccharide-protein glycosyltransferase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P39656

MASS(Da):50801

GeneID:1650

Synonyms:DDOST KIAA0115 OST48 OK/SW-cl.45

Gene names:DDOST

Standard solution:48ng/mL