Human Diacylglycerol-O-Acyltransferase Homolog 1, DGAT1 ELISA Kit

SKU: E2652Hu

Size:96 Tests-1 Kit

Background:Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed: 16214399, PubMed: 18768481, PubMed: 28420705, PubMed: 9756920, PubMed: 32433611, PubMed: 32433610). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed: 18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed: 16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed: 18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed: 16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester Synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed: 28420705).

Research_area:Others

Applications:ELISA

Target_protein:DGAT1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.66ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Diacylglycerol-O-Acyltransferase Homolog 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75907

MASS(Da):55,278

GeneID:8694

Synonyms:ACAT-related gene product 1;Acyl-CoA retinol O-fatty-acyltransferase;ARAT;DGAT 1;DGAT1;Diacylglycerol O-acyltransferase 1;Diglyceride acyltransferase;Retinol O-fatty-acyltransferase

Gene names:DGAT1

Standard solution:2400ng/L