Human Cytochrome P450 2B6, CYP2B6 ELISA Kit

SKU: E3083Hu

Size:96 Tests-1 Kit

Background:A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed: 21289075, PubMed: 12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed: 21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed: 21289075, PubMed: 12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed: 11695850, PubMed: 22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed: 11695850). Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.

Research_area:Others

Applications:ELISA

Target_protein:CYP2B6

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.77ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome P450 2B6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20813

MASS(Da):56,278

GeneID:1555

Synonyms:1,4-cineole 2-exo-monooxygenase;CYP2B6;CYPIIB6;Cytochrome P450 2B6;Cytochrome P450 IIB1

Gene names:CYP2B6

Standard solution:4800ng/L