Human Cytochrome P450 11B1, Mitochondrial, CYP11B1 ELISA Kit

SKU: E5157Hu

Size:96 Tests-1 Kit

Background:A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed: 18215163). Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively (PubMed: 18215163). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed: 18215163).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:CYP11B1

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.94ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome P450 11B1, Mitochondrial

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15538

MASS(Da):57,573

GeneID:1584

Synonyms:CYP11B1;CYPXIB1;Cytochrome P450 11B1, mitochondrial;Cytochrome P450C11;Cytochrome P-450c11;Steroid 11-beta-hydroxylase, CYP11B1

Gene names:CYP11B1

Standard solution:3200ng/L