Human Coronin 1C, CORO1C ELISA Kit

SKU: E2450Hu

Size:96 Tests-1 Kit

Background:Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed: 25074804, PubMed: 25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed: 25074804, PubMed: 25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed: 30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed: 30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). [Isoform 3]: Involved in myogenic differentiation.

Research_area:Cell Biology

Applications:ELISA

Target_protein:CORO1C

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.19ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Coronin 1C

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9ULV4

MASS(Da):53,249

GeneID:23603

Synonyms:CORO1C;Coronin-1C;Coronin-3;hCRNN4

Gene names:CORO1C

Standard solution:6400ng/L