Human Core Binding Factor alpha 1,RUNX2;CBFA1 ELISA KIT

SKU: E5119Hu

Size:96 Tests-1 Kit

Background:Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}.

Research_area:

Applications:ELISA

Target_protein:RUNX2

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.69ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Core Binding Factor alpha 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13950

MASS(Da):56648

GeneID:860

Synonyms:RUNX2 AML3 CBFA1 OSF2 PEBP2A

Gene names:RUNX2

Standard solution:4800ng/L