Human Complement C4-A, C4A ELISA Kit

SKU: E6926Hu

Size:96 Tests-1 Kit

Background:Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Research_area:Others

Applications:ELISA

Target_protein:C4A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023μg/ml

Detection range:0.05-20ug/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Complement C4-A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P0C0L4

MASS(Da):192,785

GeneID:720721

Synonyms:Acidic complement C4;C 4A;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2;C4A;C4a anaphylatoxin;C4b-A;C4d-A;Complement C4 beta chain;Complement C4 gamma chain;Complement C4-A;Complement C4-A alpha chain

Gene names:C4A

Standard solution:24μg/ml