Human Chromobox Protein Homolog 3, CBX3 ELISA Kit

SKU: E2895Hu

Size:96 Tests-1 Kit

Background:Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:CBX3

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.22ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Chromobox protein homolog 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13185

MASS(Da):20,811

GeneID:11335

Synonyms:CBX3;Chromobox protein homolog 3;HECH;Heterochromatin protein 1 homolog gamma;HP1 gamma;HP1-GAMMA;HP1Hs-gamma;Modifier 2 protein

Gene names:CBX3

Standard solution:1280ng/L