Human Caspase 3, CASP3 ELISA Kit

SKU: E4804Hu

Size:96 Tests-1 Kit

Background:Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed: 7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed: 7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed: 7596430). Involved in the cleavage of huntingtin (PubMed: 8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed: 21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 23152800).

Research_area:Cell Biology

Applications:ELISA

Target_protein:CASP3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.027ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P42574

MASS(Da):31,608

GeneID:836

Synonyms:Apopain;CASP 3;CASP3;CASP-3;Caspase-3;Caspase-3 subunit p12;Caspase-3 subunit p17;CPP-32;Cysteine protease CPP32;Protein Yama;SCA-1;SREBP cleavage activity 1

Gene names:CASP3

Standard solution:24ng/ml