Human Calcium Calmodulin-dependent Protein Kinase Type 2 Subunit Beta, CAMK2B ELISA Kit

SKU: E6579Hu

Size:96 Tests-1 Kit

Background:Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Research_area:Cell Biology; Neuroscience; Signal Transduction; Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:CAMK2B

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.53ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Calcium/calmodulin-dependent protein kinase type 2 subunit beta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13554

MASS(Da):72,678

GeneID:816

Synonyms:Calcium/calmodulin-dependent protein kinase type II subunit beta;CaM kinase II subunit beta;CAM2;CAMK2;CAMK2B;CAMKB;CaMK-II subunit beta;CaMKIIbeta;MRD54;

Gene names:CAMK2B

Standard solution:3200ng/L