Human Bone Morphogenetic Protein 6, BMP-6 ELISA Kit

SKU: E1480Hu

Size:96 Tests-1 Kit

Background:Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (PubMed:31019025). Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B (PubMed:18070108). In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (PubMed:33021694).

Research_area:Signal Transduction; Cell Biology; Stem Cells

Applications:ELISA

Target_protein:BMP-6

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.23mg/L

Detection range:0.5-150mg/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bone Morphogenetic Protein 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22004

MASS(Da):57,226

GeneID:654

Synonyms:BMP-6;Bone morphogenetic protein 6;VG-1-R;VG-1-related protein;VGR;VGR1;VGR-1

Gene names:BMP6

Standard solution:160mg/L