Human Biogenesis of Lysosome-related Organelles Complex 1 Subunit 1, BLOC1S1 ELISA Kit

SKU: E6559Hu

Size:96 Tests-1 Kit

Background:Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.

Research_area:Cardiovascular; Signal Transduction

Applications:ELISA

Target_protein:BLOC1S1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.68ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Biogenesis of lysosome-related organelles complex 1 subunit 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78537

MASS(Da):17,263

GeneID:2647

Synonyms:Biogenesis of lysosome-related organelles complex 1 subunit 1;BLOC-1 subunit 1;BLOC1S1;BLOS1;BORCS1;GCN5L1;GCN5-like protein 1;MICoA;Protein RT14;RT14

Gene names:BLOC1S1

Standard solution:2400ng/L