Human Biglycan ELISA Kit PicoKine®

SKU: EK1357

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: BGN

Specificity: Natural and recombinant human Biglycan

Background: Biglycan (BGN) is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. It is an important structural component of articular cartilage and participates in the assembly of the chondrocyte extracellular matrix through formation of protein interactions with type VI collagen and large proteoglycan aggregates. In humans, Biglycan is encoded by the BGN gene. It is mapped to Xq28. Biglycan is believed to play a role in the mineralisation of bone, and its core protein binds to the growth factors BMP-4 and influences its bioactivity. It has been reported that the presence of biglycan is necessary for BMP-4 to exert its effects on osteoblasts. There is also evidence that biglycan can bind to TGF-beta 1. In addition, Biglycan plays an important role in cell signaling.

Immunogen: Expression system for standard: NS0; Immunogen sequence: D38-K368

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Reference:

Uniprot ID: P21810

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 633

Protein Name: Biglycan

Gene Full Name: biglycan

Synonyms: A6NLG9; BGN; biglycan; Bone/cartilage proteoglycan I; DSPG1; PG S1; PGI; SLRR1A