Human BCL2;Adenovirus E1B 19 kDa Protein-Interacting Protein 3-Like,BNIP3L ELISA KIT

SKU: E7383Hu

Size:96 Tests-1 Kit

Background:Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.

Research_area:

Applications:ELISA

Target_protein:BNIP3L

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:BCL2;Adenovirus E1B 19 kDa Protein-Interacting Protein 3-Like

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O60238

MASS(Da):23930

GeneID:665

Synonyms:BNIP3L BNIP3A BNIP3H NIX

Gene names:BNIP3L

Standard solution:24ng/ml