Human B lymphocyte stimulator,BLyS ELISA KIT

SKU: E0410Hu

Size:96 Tests-1 Kit

Background:Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}.; [Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.

Research_area:

Applications:ELISA

Target_protein:TNFSF13B

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.58ng/L

Detection range:5-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:B lymphocyte stimulator

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y275

MASS(Da):31223

GeneID:10673

Synonyms:TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738

Gene names:TNFSF13B

Standard solution:1600ng/L