Human Anthrax Toxin Receptor 2, ANTXR2 ELISA Kit

SKU: E2398Hu

Size:96 Tests-1 Kit

Background:Necessary for cellular interactions with laminin and the extracellular matrix. (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis (PubMed:12700348, PubMed:15243628, PubMed:15326297). Binding of PA leads to heptamerization of the receptor-PA complex (PubMed:12700348, PubMed:15243628, PubMed:15326297). Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway (PubMed:12551953, PubMed:15337774). In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm (PubMed:12551953, PubMed:15337774).

Research_area:Others

Applications:ELISA

Target_protein:ANTXR2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.26ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Anthrax Toxin Receptor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P58335

MASS(Da):53,666

GeneID:118429

Synonyms:Anthrax toxin receptor 2;ANTXR2;Capillary morphogenesis gene 2 protein;CMG2;CMG-2;HFS;ISH;JHF

Gene names:ANTXR2

Standard solution:2400ng/L