Human Adenomatosis Polyposis Coli Protein, APC ELISA Kit

SKU: E2284Hu

Size:96 Tests-1 Kit

Background:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Research_area:Others

Applications:ELISA

Target_protein:APC

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.16ng/ml

Detection range:2-700ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Adenomatosis Polyposis Coli Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P25054

MASS(Da):311,646

GeneID:324

Synonyms:Adenomatous polyposis coli protein;APC;Deleted in polyposis 2.5;Protein APC

Gene names:APC

Standard solution:800ng/ml