Human Acyl-protein Thioesterase 1, LYPLA1 ELISA Kit

SKU: E4903Hu

Size:96 Tests-1 Kit

Background:Acts as a acyl-protein thioesterase (PubMed: 19439193, PubMed: 20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed: 20418879). Has depalmitoylating activity toward KCNMA1 (PubMed: 22399288). Could also depalmitoylate ADRB2 (PubMed: 27481942). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed: 19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed: 19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed: 21393252).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:LYPLA1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.32ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Acyl-Protein Thioesterase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75608

MASS(Da):24,670

GeneID:10434

Synonyms:Acyl-protein thioesterase 1;APT-1;hAPT1;LPL-I;LYPLA 1;LYPLA1;Lysophospholipase 1;Lysophospholipase I;LysoPLA I;

Gene names:LYPLA1

Standard solution:3200ng/L