Human 60S Ribosomal Protein L13A, RPL13A ELISA Kit

SKU: E4883Hu

Size:96 Tests-1 Kit

Background:Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:RPL13A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:60S Ribosomal Protein L13A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P40429

MASS(Da):23,577

GeneID:23521

Synonyms:23 kDa highly basic protein;60S ribosomal protein L13a;Large ribosomal subunit protein uL13;RPL 13A;RPL13A

Gene names:RPL13A

Standard solution:24ng/ml