HMGB-1 Polyclonal antibody

SKU: AN006010L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:HMGB-1

Target Synonym:High mobility group protein 1;high mobility group protein B1;high-mobility group box 1;HMG1;HMG-1;HMG1DKFZp686A04236;HMG3;HMGB1;SBP-1;Chromosomal protein;DKFZp686A04236;High mobility group 1;High mobility group box 1;high-mobility group (nonhistone chromosomal) protein 1;HMGB 1;nonhistone;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein;SBP;HMGB;High Mobility Group Protein;High mobility group protein B;HMG;HMG-1;HMG1;HMG3;SBP-1;HMGB1;Amphoterin;High Mobility Group Protein 1;High mobility group protein B1;High mobility group protein 1 (HMG-1)

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P09429

Accession:

Background:Human High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 70 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 30 aa C-terminal region that contains only Asp and Glu . Residues 27‑43 and 178‑184 contain a NLS. Posttranslational modifications of the molecule have been reported, with acetylation occurring on as many as 17 lysine residues.

Concentration:1 mg/mL

Immunogen:Recombinant Human HMGB-1 protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:24 kDa

ObservedMW:29 kDa