HLA-DRB3 Polyclonal Antibody

SKU: E-AB-18084

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: HLA-DRB3

Target Synonym: DR beta 3 chain;DR7;DRB3;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DR beta 3 chain;HLA class II histocompatibility antigen DRB1 7 beta chain;HLA DR3B;HLA-DRB3;Human leucocyte antigen DRB3;Major histocompatibility complex class II DR beta 3;MGC117330;MHC class II antigen DR beta 3 chain;MHC class II antigen DRB3;MHC class II HLA DR beta 3 chain

Research Areas: Immunology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P79483

Accession:

Background: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Concentration: 1.44 mg/mL

Immunogen: Synthetic peptide of human HLA-DRB3

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:20-1:100

Calculated MW:

ObservedMW: