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Gene Bio Systems

HINT1 Antibody - Cat. #: CSB-PA05639A0Rb

HINT1 Antibody - Cat. #: CSB-PA05639A0Rb

CSB-PA05639A0Rb

€331,95 EUR
€331,95 EUR
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Size :50ug

Clone Number:

Aliases:Adenosine 5' monophosphoramidase antibody; Adenosine 5''-monophosphoramidase antibody; HINT 1 antibody; HINT1 antibody; HINT1_HUMAN antibody; Histidine triad nucleotide binding protein 1 antibody; Histidine triad nucleotide-binding protein 1 antibody; PKCI 1 antibody; PKCI-1 antibody; PKCI1 antibody; PRKCNH1 antibody; Protein kinase C inhibitor 1 antibody; Protein kinase C interacting protein 1 antibody; Protein kinase C-interacting protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49773

Immunogen:Recombinant Human Histidine triad nucleotide-binding protein 1 protein (2-126AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5\\\'monophosphoramidate (AMP-NH2), adenosine 5\\\'monophosphomorpholidate (AMP-morpholidate) and guanosine 5\\\'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5\\\'-O-phosphorothioate and guanosine 5\\\'-O-phosphorothioate to the corresponding nucleoside 5\\\'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HINT1

Research Areas:Epigenetics and Nuclear Signaling; Cancer

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