HIF1AN Antibody, Biotin conjugated - Cat. #: CSB-PA865160LD01HU

SKU: CSB-PA865160LD01HU

Size :50ug

Clone Number:

Aliases:DKFZp762F1811 antibody; Factor inhibiting HIF-1 antibody; Factor inhibiting HIF1 antibody; FIH 1 antibody; FIH-1 antibody; FIH1 antibody; FLJ20615 antibody; FLJ22027 antibody; HIF1AN antibody; HIF1N_HUMAN antibody; Hypoxia inducible factor 1 alpha inhibitor antibody; Hypoxia inducible factor 1 alpha subunit inhibitor antibody; Hypoxia inducible factor asparagine hydroxylase antibody; Hypoxia-inducible factor 1-alpha inhibitor antibody; Hypoxia-inducible factor asparagine hydroxylase antibody; Peptide aspartate beta dioxygenase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NWT6

Immunogen:Recombinant Human Hypoxia-inducible factor 1-alpha inhibitor protein (2-254AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Hydroxylates HIF-1 alpha at \'Asp-803\' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HIF1AN

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular